Prof.Shekhar M KUMTA
 
 
1. Present Position
 
Professor, Dept. of Orthopaedics & Traumatology, The Chinese University of Hong Kong
 
In this capacity, I am responsible for the Musculoskeletal Tumor Unit, which is a designated Centre of Excellence and a tertiary referral unit within the Hospital Authority Hong Kong. I am thus primarily responsible for the comprehensive clinical management of ALL patients with musculoskeletal tumors, (benign and malignant, primary and metastatic) that present to us from regional hospitals and private practitioners.
 
 
2. Research Experience
 
My research has mainly focused on problems related to:
1. Materials for reconstruction following tumors fractures
2. Prognostic Factors and Tumor Markers in Malignant and locally aggressive tumors
3. Clinical problems associated with musculoskeletal neoplasms
 
 
3. Research Grants   (Principal Investigator)
 
1.
Degradation Characteristics of Bioabsorbale Implants in Rabbit Bone.
  CUHK Direct Grant 1990-91
   
2. Studies on the Revascularisation of Cryopreserved and Fresh Femoral Allografts Following Vascular Bundle Implantation in Rats.
  CUHK Direct Grant 1992-93
   
3. The Use of Vascularized Bone as an Aid to Enhance the Incorporation of Bone Allografts in a Rabbit Model.
  CUHK Direct Grant 1993-94
   
4. The Use of Adriamycin Binding Assay as a Test to Determine the Chemosensitivity of Patients with Osteogenic Sarcoma.
  CUHK Mainline Research Scheme 1994
   
5. Tumour Specific Alkaline Phosphatase in Osteosarcoma.
  Research Grants Council 1995-96
   
6. Investigating the Mechanical and Biochemical Barrier Effect of the Physeal Growth Plate Towards Osteosarcoma Extension.
  CUHK Direct Grant 1995-96
   
7. Quantitative Studies of P-glycoprotein Related Biochemical Markers to Monitor Drug Resistance in malignant musculoskeletal tumours.
  Direct Grant for Research 1997-98
   
8. Towards Understanding the Molecular Events of Histogenesis and Biological Behaviour of Giant Cell Tumour of Bone ¡V The Significance of Urokinase Type Plasminogen Activating System and Osteoclast Regulatory Factors.
  CUHK Direct Grant 2000-01
   
9. Anti-angiogeneic & Antiresportive Actions of Bisphosphonates & COX-2 Inhibitors on Osteosarcoma Cells (Surrogate Osteoblasts)
  Direct Grant for Research 2000-01
   
10. Bisphosphonates Induce the Healing and Consolidation of Osteolytic Secondary Bone Tumors.
  CUHK Direct Grant for Research 2001-02
   
11. Aminobisphosphonates and Farnesyl Transferase Inhibitors as Adjuvants in the Treatment of Giant Cell Tumor of Bone.
  CUHK Direct Grant for Research 2000-04
   
12. A Web-based Self Assessment Programme for Final Year Orthopaedic Students.
  Courseware Development Grant (Special Grant) 2001
   
13. Promotion of Experience Sharing and Sharing of Good Teaching and Learning Practices ¡V Teaching focused workshops to enable the development of interactive web-based strategies designed to foster critical thinking in students
  Teaching Development Grant 1998/2001 ¡V 1st Tranche
   
14. Development of a curriculum in Clinical Orthopaedics and the Musculoskeletal System designed to promote critical thinking skills and evidence based reasoning for undergraduate students.
  Teaching Development Grant 1999-2001 (Co-PI)
   
15. Bisphosphoates Induce the Healing and Consolidation of Osteolytic Secondary Bone Tumors.
  CUHK Direct Grant 2001-02
   
16. Formative Assessment Case Studies (FACS) Establishing Life-Long Learning Skills in Health Science Students. (CO-PI)
  Teaching Development Grant 2001-04 (Co-PI)
   
17. The Learning Objects Initiative. (Co-investigator)
  Teaching Development Grant 01-04 (Co-PI)
   
18. Potential Anti-tumor Effects of Aminobisphosphonates and Prenyl Transferase Inhibitors on Giant Cell Tumor of Bone.
  RGC Earmarked Grant 2005-06
   
19. Transcriptional Regulation of RANKL Promoter in Giant Cell Tumor of Bone.
  RGC Earmarked Grant 2007-08
   
20. Joint Collaborative Research in Fabrication and Application of Functional Gradient Tumor Bone Repair Materials Based on Rapid Prototyping Techniques.
  NSFC/RGC Joint Research Scheme 2007
   
21. Development of a Virtual Patient Environment to Facilitate Teaching of Medical Students.
  Teaching Development Grant 05-08 Triennium (Co-supervisor)
   
22. To Review and Refine a Repository of Case Simulations Developed by the Faculty of Medicine and to Enable Their Use in Faculty-wide Summative Assessments of Undergraduate Medical Students.
  Teaching Development Grant 05-08 Triennium
   
23. Developing Appropriate Student Learning Outcomes: Balancing Pedagogical Latitude & Accountability in Educating Medical Students.
  Teaching Development Grant 05-08 Triennium (Co-supervisor)
   
24. Use of a Wizard Template to Facilitate Construction of Quality Extend Matching Questions.
  Teaching Development Grant 05-08 Triennium (Co-supervisor)
   
 
 
4. Ten Most representative publications
 
1. Huang L, Xu JK, Li K, Zheng MH, Kumta SM.
  Thapsigargin Potentiates Trail-induced Apotosis in Giant Cell Tumor of Bone.
  Bone 2004 34(6):971-81
   
2. Kumta SM, Huang L, Cheng YY, Chow LT, Lee KM, Zheng MH
  Expression of VEGF and MMP-9 in Giant Cell Tumor of Bone and other osteolytic lesions.
  Life Sci. 2003 Aug 1;73(11):1427-36
   
3. Andrew IC, Huang L, Xu JK, Kumta SM, Wood D, Zheng MH
  Expression and Localization of Extracellular Matrix Metalloproteinase Inducer in the Giant Cell Tumor of Bone
  J Cell Biochem. 2003 Aug 15;89(6):1154-63
   
4. Cheng YY, Huang L, Lee KM, Lai FM, Tam JSK, Kumta SM
  Cytochemical and ultrastructural study of the osteoclast-like giant cells of GCT following bisphosphonate administration
  Ultrastructural Pathology. (Accepted on May 7, 03)
   
5. Huang L, Cheng YY, Chow TC, Zheng MH, Kumta SM
  Receptor Activator of NF-kB Ligand (RANKL) is expressed in chondroblastoma: Possible involvement in osteoclastic giant cell recruitment
  Molecular Pathology 2003 April;56:116-120
   
6. Huang L, Cheng YY, Chow LTC, Zheng MH, Kumta SM
  Tumor Cells Produce Receptor Activator of NF-kappa B Ligand (RANKL) in skeletal Metastases
  Journal of Clinical Pathology 2002 Nov;55(11):877-8
   
7. Huang L, Xu J, Kumta SM, Zheng MH
  Gene expression of glucocorticoid receptor alpha and beta in giant cell tumour of bone: evidence of glucocorticoid-stimulated osteoclastogenesis by stromal-like tumour cells
  Mol Cell Endocrinol. 2001 Jul 5;181(1-2):199-206
   
8. Zheng MH, Xu Jiake, Robbins P, Pavlos N, Wysocki S, Kumta SM, Wood DJ, Paradimitriou JM
  Gene Expression of Vasucular Endothelial Growth Factor in Giant Cell Tumors of Bone
  Hum Pathol. 2000 July; 31(7):804-12
   
9. Kumta SM, Leung PC, Chow TC, To SH, Lee KM, Cheng SH
  Assessment of Chemosensitivity in Patients with Osteogenic Sarcoma Using the Doxorubicin Binding Assay
  J Surg Oncol 1998 Jul;68:169-72
   
10. Kumta SM, Leung PC, Yip K, Hung LK, Panozzo A, Kew J
  Vascularized bone grafts in the treatment of juxta-articular giant-cell tumors of the bone
  J Reconstr Microsurg 1998 Apr;14(3):185-90
   


5. Research Related prizes and awards
 
1. Best Paper Award
  Cheng YY, Huang L, Kumta SM
  Alendronate Regulates Cell Migration and MMP-2 Secretion in Human Osteosarcoma Cell Lines
  The 21st Hong Kong Orthopaedic Association Annual Congress vol.5. Hong Kong SAR: Hong Kong Journal of Orthopaedic Surgery 2001 Nov;5 (Suppl):S8
   
2. Poster Award
  Cheng YY, Huang L, Lee KM, Lai FM, Tam JSK, Kumta SM
  A Study of the Morphological Changes in Osteoclast-like Giant Cells Following Bisphosphonates Treatment
  The 22nd Hong Kong Orthopaedic Association Annual Congress. Hong Kong SAR: Hong Kong Journal of Orthopaedic Surgery. (Vol. 6 Suppl, November 2002)